Carlos Corberán has urged his Albion side to focus solely on their own performance against Sheffield United, regardless of any permutations around the fixture's result.
Wednesday night's meeting (ko 8pm) is a crucial one for both clubs, with a Blades victory securing them promotion to the Premier League, and a Baggies win firing them firmly into top-six contention.
But, backed by "thousands of people" both at Bramall Lane and home, the boss believes his side need to ignore the noise and concentrate on themselves.
He said: "It’s the most important thing to focus on the performance. We know we’re going to be playing against a very demanding team in a stadium I expect to be on fire to help their team win three points.
"But this can only increase our motivation to play the game. It can only increase our energy in the game, which is going to be very important.
"Even if our fans cannot be filling the stadium, we know they they will be behind us whether watching on TV or following the team and supporting from home.
"This is something that is important to know, that you’re never going to be alone on the football pitch, you’re going to have thousands of people supporting you and you need to connect with them, even if they’re not all there."
Albion missed the chance to put themselves in the Sky Bet Championship Play-Off places on Sunday afternoon following their 2-1 defeat at home to Sunderland.
However, the boss pointed out that despite the result, there were plenty of positives to emerge from the performance which the players must take into Wednesday's clash.
He added: "Defeats are always difficult to manage, nobody likes to lose football games.
"Against Sunderland I was watching a team that was competing a lot, trying to use our strength to win the game. Unfortunately we couldn’t manage that, but we need to keep showing that we are a competitive team.
"What we couldn’t do the other day, we need to use tomorrow to add the three points. This is the target we have for every game."
The clash against the Blades also marks Albion's 5,000th league fixture as a club.
The boss highlighted the tremendous milestone, admitting that it shows the level of responsibility staff and players have in playing their part at The Hawthorns.
"It shows how big this club is. Because when you play this many games you realise the history of this club," he said.
"This is the responsibility and the commitment that we have working in this club. We know very well how big West Bromwich Albion Football Club is."