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Steve Clarke's side are 18/5 to record their fifth triumph on the road this season, while Southampton are 10/11 favourites.
Elsewhere, newly-crowned Premier League champions Manchester United are under the spotlight again this weekend as they head to Robin van Persie's former club Arsenal.
Sir Alex Ferguson’s men are 11/5 to dent the top-four hopes of their old rivals, but the Gunners are 5/4 favourites to beat the Red Devils at the Emirates.
There are no shortage of six-pointers as Stoke (11/10) and Norwich (3/1) try to stay clear of trouble, Reading (13/8) and QPR (17/10) take a last shot at defying the odds and Villa (5/4) host Sunderland (12/5) on Monday night.
Now you can back Albion during all the big matches too, as in-play betting is now available at wba.betbutler.co.uk
Click the Live button on the left and remember whatever you're backing, every bet benefits the club you love!
Odds correct at time of writing.