Albion have never won their first away game of a Barclays Premier League campaign, having drawn four and lost three.
Shane Long scored 22 goals in 87 appearances for the Baggies between August 2011 and January 2014.
The Saints finished eighth in the Premier League last season while Albion placed the same position a year earlier.
Chris Baird enjoyed nine years with Southampton before moving to Fulham. He made 79 appearances for the club, including their 2003 FA Cup Final defeat by Arsenal.
Last time out
HOME: Barclays Premier League, Saturday, August 17, 2013, Albion 0 Southampton 1 (Lambert pen 90)
AWAY: Barclays Premier League, Saturday, January 11, 2014, Southampton 1 (Lallana 66) Albion 0
Form guide (last six league matches)
Last league match line-ups
ALBION (v Sunderland – home D 2-2): Foster, Wisdom, Dawson, Olsson, Pocognoli, Mulumbu, Gardner (Yacob 84), Dorrans (Sessegnon 84), Berahino, Brunt (c) (Baird 76), Anichebe. Subs not used: Myhill (gk), Ideye, Davidson, O’Neil.
SOUTHAMPTON (v Liverpool – away L 2-1): Forster; Clyne, Fonte (c), Yoshida, Bertrand, Wanyama, Schneiderlin, Steven Davis (Isgrove 82), Ward-Prowse, Tadić (Long 73), Pellè. Subs not used: Davis (gk), Taïder, Cork, Hooiveld, Stephens.
Southampton team news
Gaston Ramirez remains a doubt with a knee injury while Florin Gardos could return from a hamstring problem.
Roger East will referee Saturday's game. The Wiltshire official last oversaw the Baggies a year ago this weekend in a goalless draw at Everton. He dished out 102 yellow and two red cards in 29 games last term.
Selected odds from Sky Bet:
Southampton to win: 17/20
Albion to win: 3/1
Saido Berahino to score first: 7/1
Shane Long to score first: 9/2
If you fancy a flutter with the club's official online betting partner, click here
Albion have sold more than 1,500 from their initial allocation of 2,200 and tickets remain on general sale. For more information, click here
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