Two changes and Rosenberg named on benchMARC-Antoine Fortune is handed his first Baggies start of the season in a three-pronged attack.
He replaces Peter Odemwingie, who is left out altogether due to a minor injury he picked up in training, as one of two changes to the starting XI that beat Liverpool 3-0 last weekend.
Graham Dorrans returns after missing the Reds clash due to family reasons and goes straight into Steve Clarke’s line-up at the expense of Zoltan Gera, who drops to the bench.
Striker Markus Rosenberg makes an Albion matchday squad for the first time since his summer move and is among the substitutes at White Hart Lane.
He is joined in the dugout by Billy Jones, who missed the season-opener because of food poisoning.
The other men to make way from the 18-man party are Gonzalo Jara Reyes and Yassine El Ghanassy.
Andre Villas-Boas makes two changes to the Spurs team that lost 2-1 at Newcastle last weekend.
Jan Vertonghen and Rafael Van Der Vaart come in for Younes Kaboul, who misses out altogether, and the benched Gylfi Sigurdsson.
SPURS (4-2-3-1): Friedel; Walker, Vertonghen, Gallas, Assou-Ekotto; Sandro, Livermore; Lennon, Van der Vaart, Bale; Defoe. Subs: Cudicini (gk), Caulker, Naughton, Jenas, Townsend, Sigurdsson, Adebayor.
ALBION (4-2-1-3): Foster; Reid, McAuley, Olsson, Ridgewell; Mulumbu, Yacob; Morrison; Fortune, Long, Dorrans. Subs: Myhill (gk), Brunt, Rosenberg, Jones, Gera, Dawson, Lukaku.
REFEREE: M Dean (Wirral).