STEVE Clarke has made three changes to the side that drew 1-1 with Newcastle at The Hawthorns last Saturday.
Steven Reid returns in place of last weekend’s goalscorer Billy Jones at right-back.
Jones has recovered from a gashed leg in time to be named as a substitute for the St Mary’s clash.
Goran Popov, who picked up a knock during training yesterday, makes way for Liam Ridgewell at left-back.
Shane Long also starts for Albion as skipper Chris Brunt is ruled out with a knee problem.
Donervorn Daniels features on Clarke’s bench for the first time - with fellow youngster Kemar Roofe making way after sustaining an injury in Sunday’s Under-21s fixture against the Saints.
Mauricio Pochettino has named an unchanged starting XI to the one that fought out a goalless draw with Swansea last weekend, as his side look to extend their six-game unbeaten run.
ALBION (4-2-3-1): Foster; Reid, McAuley, Olsson (C), Ridgewell; Yacob, Dorrans; Fortune, Morrison, Lukaku; Long. Subs: Myhill (gk); Thomas, Jones, Odemwingie, Rosenberg, D Daniels, Tamas.
SOUTHAMPTON (4-2-3-1): Boruc; Clyne, Yoshida, Hooiveld, Fox; Schneiderlin, Cork; S Davis, Lallana (c),Rodriguez; Lambert. Subs: K Davis (gk), Fonte, Ramírez, Forren, Guly, Mayuka, Puncheon.
REFEREE: Robert Madley (West Yorkshire)