Albion have not beaten United in 12 Barclays Premier League meetings, losing ten and drawing two - both stalemates came at Old Trafford.
The Baggies last beat United in the League Cup in December 2003, when Bernt Haas and Scott Dobie goals secured a 2-0 win at The Hawthorns.
Wayne Rooney has scored five goals in his last five games against Albion but has been ruled out of this game with a knee injury.
Albion (23) have conceded five fewer goals than the Red Devils (28) this term, with only Chelsea, Manchester City, Arsenal, Stoke and West Ham able to boast a better overall defensive record.
The Baggies have scored four or more goals against United on 12 different occasions, while the Red Devils have netted four against Albion 11 times.
Albion's last league win over United was a 2-0 success in March 1984, when Steve MacKenzie and Cyrille Regis scored.
Their last league victory over the Red Devils at Old Trafford came 34 years ago this weekend, and was a 5-3 thriller in December 1978, when Tony 'Bomber' Brown bagged a double to add to Len Cantello, Laurie Cunningham and Regis goals.